Published Date : Dec 18, 2018
A team of researchers have suggested a novel protein that may be quite promising therapeutic target for the treatment of prevention of metabolic disorders. This study is being led by Suresh Alahari, PhD and Fred Brazda, a professor of Microbiology and Biotechnology at the LSU Health in New Orleans. This study has also reported that the metabolic distinctions between the female and male mice. These research findings have been published in the December 2018 issue of the International Journal of Obesity.
The team of researchers have conducted their studies in human tissue as well as a mouse model so as to advance their understanding of the role of the Nischarin. It is a novel protein that has been discovered in the lab of Alahari in the insulin resistance and fat distribution that is leading to obesity and diabetes. The functions of Nischarin as a molecular scaffold and is also involved in the pathway of insulin signaling.
The disruption of this novel protein has resulted in insulin resistance in female mice and not in the male mice, which states that Nischarin protects against the diabetes in females. Furthermore, Suresh Alahari states that their human data indicate that this protein expression is suppressed in the fat tissue of the obese humans. The higher expressions of the Nischarin is likely to correlate with the enhanced glucose and lipid metabolism, along with a lower BMI. Moreover, the team of researchers have also found the differences in the gender in terms of reduction in glucose tolerance in females, fat distribution, and rising insulin resistance.