Published Date : Mar 28, 2016
Primary immunodeficiency diseases are a class of 200+ immune disorder wherein a part of the immune system in the body is either absent or does not function properly. Primary immunodeficiency diseases are mostly genetic in nature that happens due to a single-gene defect and are passed from either one or both parents. In its common form, primary immunodeficiency diseases happen due to problems in the DNA, which results in missing white blood cells that the immune system is composed of.
Primary immunodeficiency diseases may have differences in expression, but have the common feature of increased susceptibility to infection. Primary immunodeficiency diseases if left untreated or if not diagnosed properly can led to chronic health conditions, disability, reduced working capacity, poor quality of life of patients and their families, permanent damage to organs, and even death. However, primary immunodeficiency diseases are a rarity and are prevalent in the ration of 1:10,000 live births, which does not include the prevalence statistics of immunoglobulin deficiency.
Typically, primary immunodeficiency diseases of serious type manifests in infancy. Nevertheless, if it is present in milder forms it manifests in the form of recurrent infections before primary immunodeficiency disease is established. In some cases, the disease remains undiagnosed until the age of 25-30 years.
Primary immunodeficiency diseases are indicative of certain vital signs;
Some immunodeficiency diseases are not primary and are not related to genetic reasons. These are secondary immune deficiency diseases that affect the immune system on account of environmental reasons. HIV, chemotherapy, severe burns, and nutrition are some of the external causes related to secondary immunodeficiency diseases.