Calorie Restriction Could Help Humans Defy Age-related Diseases

Published Date : Mar 26, 2018

A new study has showed that cutting down calorie intake by as much as 15% for 2 years in humans had a massive impact on body metabolism, slowed down aging, and proved to be more protective against age-related health conditions. The research, published in the scientific journal Cell Metabolism, suggests that calorie restriction brought about a reduction in systematic oxidative stress, which has been long associated with age-related neurological diseases such as Parkinson’s diseases and Alzheimer’s as well as chronic conditions such as diabetes and cancer.

The study, named CALERIE, was the first of its kind randomized controlled study observed to study the metabolic effects of restricting calorie intake in non-obese humans. The second phase of the study studied 53 non-obese people, men and women, aged between 21 and 50. For all these individuals, calorie intake was reduced by 15% over the period of 2 years. All the people who participated in the study undertook additional measurements for oxidative stress and metabolism.

Calorie intake for each subject was individually calculated through the amount of isotopes that were absorbed by the tissues and molecules of the participants over a period of two weeks, a technique that pinpoints the weight-maintenance calorie level accurately. The subjects that were a part of the calorie restriction group lost nearly 9 kg, although a particular diet and weight loss was not a goal of the study. It was also noted that the subjects did not experience any kind of adverse effects such as excessive bone loss, anemia, or menstrual disorders. Both the trials in fact resulted in improvement in health- and mood-related quality of life.