Trelstar (Prostate Cancer) - Forecast and Market Analysis to 2022




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Trelstar (Prostate Cancer) - Forecast and Market Analysis to 2022


GlobalData has released its new PharmaPoint Drug Evaluation report, “Trelstar (Prostate Cancer) - Forecast and Market Analysis to 2022”. The recent approvals of second-line metastatic castration-resistant prostate cancer (mCRPC) therapies like J&J’s Zytiga (abiraterone acetate) and Medivation/Astellas’ Xtandi (enzalutamide) will drive strong market growth over the next decade. 

These safe and orally administered treatments will provide safety and convenience benefits over the current standard of care, chemotherapy with docetaxel, while prolonging the overall survival of patients with mCRPC. The December 12, 2012 FDA approval of Zytiga for the added indication of chemotherapy-naïve mCRPC marks the onset of a new treatment paradigm for the disease, in which chemotherapy is relegated to second-line therapy and beyond. For patients with earlier-stage prostate cancer, androgen deprivation therapy with LHRH agonists and first-generation antiandrogens remains the standard of care for suppressing testosterone levels and temporarily controlling the disease.

Trelstar was initially developed by the Debiopharm Group, which in-licensed the drug from Tulane University. It is currently marketed under different names by a number of partners, including Watson (Trelstar, US), Ipsen (Décapeptyl, 5EU; Diphereline, Australia), and Paladin labs (Trelstar, Canada). 

Trelstar is an LHRH agonist used to achieve castrate levels of testosterone in men with advanced prostate cancer. It can be used with or without antiandrogen co-treatment, and in patients with both hormone-sensitive and castration-resistant disease. Like all LHRH agonists, including Abbott’s Lupron Depot, AstraZeneca’s Zoladex, and Sanofi’s Eligard, Trelstar acts by binding to the LHRH receptor, and prevents the pituitary gland from secreting luteinizing hormone.

  • Overview of Prostate cancer, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on Trelstar including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for Trelstar for the top nine countries from 2012 to 2022.
  • Sales information covered for the US, Japan, UK, France, Germany, Spain, Italy , Canada, and Australia 
Reasons to buy
  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for Prostate cancer
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of Trelstar performance 
  • Obtain sales forecast for Trelstar from 2012-2022 in nine markets (US, Japan, UK, France, Germany, Spain, Italy , Canada, and Australia)
Table of Contents

1 Table of Contents 5
1.1 List of Tables 6
1.2 List of Figures 6

2 Introduction 7
2.1 Catalyst 7
2.2 Related Reports 8
2.3 Upcoming Related Reports 9

3 Disease Overview 10
3.1 Etiology and Pathophysiology 10
3.1.1 Etiology 10
3.1.2 Pathophysiology 10
3.1.3 Prognosis 11
3.1.4 Quality of Life 12
3.2 Symptoms 13

4 Disease Management 14
4.1 Diagnosis and Referral Overview 14
4.2 Treatment Overview 16
4.2.1 Conservative Management Strategies 20
4.2.2 Localized Treatments 21
4.2.3 Hormone Therapy 22
4.2.4 Drug Therapies 24

5 Competitive Assessment 26
5.1 Overview 26
5.2 Strategic Competitor Assessment 27

6 Trelstar (triptorelin acetate) 30
6.1 Overview 30
6.2 Efficacy 31
6.3 Safety 31
6.4 SWOT Analysis 32
6.5 Forecast 33

7 Appendix 34
7.1 Bibliography 34
7.2 Abbreviations 38
7.3 Methodology 39
7.4 Forecasting Methodology 39
7.4.1 Number of Prostate Cancer Patients Currently Seeking Treatment 40
7.4.2 Percent Drug-treated Patients 40
7.4.3 Percent Hormone Therapy-Treated Patients 40
7.4.4 General Pricing Assumptions 41
7.4.5 Individual Drug Assumptions 42
7.4.6 Generic Erosion 43
7.5 Physicians and Specialists Included in This Study 43
7.6 Survey of Prescribing Physicians 44
7.7 About the Authors 44
7.7.1 Authors 44
7.7.2 Global Head of Healthcare 45
7.8 About GlobalData 46
7.9 Contact Us 46
7.10 Disclaimer 46

Table 1: Stage Distribution of Prostate Cancer at Diagnosis in Selected Major Markets 12
Table 2: Global Variations in Recommendations on Routine PSA Screening 14
Table 3: Most Commonly Followed Treatment Guidelines for Prostate Cancer, 2012 17
Table 4: Most Commonly Prescribed Drugs for Prostate Cancer by Class in the Global Markets, 2012 19
Table 5: Leading Treatments for Prostate Cancer, 2012 29
Table 6: Product Profile - Trelstar 31
Table 7: Trelstar SWOT Analysis, 2012 32
Table 8: Global Sales Forecasts ($m) for Trelstar, 2012-2022 33
Table 9: Physicians Surveyed, By Country 44
Figure 1: General Treatment Algorithm for Prostate Cancer, 2012 18