Xtandi (Prostate Cancer) - Forecast and Market Analysis to 2022


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47pages

GlobalData

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Xtandi (Prostate Cancer) - Forecast and Market Analysis to 2022

Summary

GlobalData has released its new PharmaPoint Drug Evaluation report, “Xtandi (Prostate Cancer) - Forecast and Market Analysis to 2022”. The recent approvals of second-line metastatic castration-resistant prostate cancer (mCRPC) therapies like J&J’s Zytiga (abiraterone acetate) and Medivation/Astellas’ Xtandi (enzalutamide) will drive strong market growth over the next decade. 

These safe and orally administered treatments will provide safety and convenience benefits over the current standard of care, chemotherapy with docetaxel, while prolonging the overall survival of patients with mCRPC. The December 12, 2012 FDA approval of Zytiga for the added indication of chemotherapy-naïve mCRPC marks the onset of a new treatment paradigm for the disease, in which chemotherapy is relegated to second-line therapy and beyond. 

For patients with earlier-stage prostate cancer, androgen deprivation therapy with LHRH agonists and first-generation antiandrogens remains the standard of care for suppressing testosterone levels and temporarily controlling the disease.

Medivation’s and Astellas’ Xtandi is approved by the FDA as a second-line therapy for patients with mCRPC. Xtandi is a FIC, triple-action androgen signaling inhibitor that was initially developed by Medivation, which entered into a collaboration agreement with Astellas. Medivation and Astellas will co-market Xtandi in the US, while Astellas retains the marketing rights for the rest of the world. 

The companies have priced Xtandi aggressively compared with its primary competitor, Zytiga, in the US. Such aggressive pricing may be a barrier to Xtandi’s reimbursement and uptake, especially in the 5EU, where there is a clear focus on cutting costs.

Scope
  • Overview of Prostate cancer, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on Xtandi including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for Xtandi for the top nine countries from 2012 to 2022.
  • Sales information covered for the US, Japan, UK, France, Germany, Spain, Italy , Canada, and Australia 
Reasons to buy
  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for Prostate cancer
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of Xtandi performance 
  • Obtain sales forecast for Xtandi from 2012-2022 in nine markets (US, Japan, UK, France, Germany, Spain, Italy , Canada, and Australia)
Table of Contents

1 Table of Contents 5
1.1 List of Tables 6
1.2 List of Figures 6

2 Introduction 7
2.1 Catalyst 7
2.2 Related Reports 7
2.3 Upcoming Related Reports 9

3 Disease Overview 10
3.1 Etiology and Pathophysiology 10
3.1.1 Etiology 10
3.1.2 Pathophysiology 10
3.1.3 Prognosis 11
3.1.4 Quality of Life 12
3.2 Symptoms 12

4 Disease Management 13
4.1 Diagnosis and Referral Overview 13
4.2 Treatment Overview 15
4.2.1 Conservative Management Strategies 19
4.2.2 Localized Treatments 20
4.2.3 Hormone Therapy 21
4.2.4 Drug Therapies 23

5 Competitive Assessment 25
5.1 Overview 25
5.2 Strategic Competitor Assessment 26

6 Xtandi (enzalutamide) 29
6.1 Overview 29
6.2 Efficacy 31
6.3 Safety 31
6.4 SWOT Analysis 32
6.5 Forecast 33

7 Appendix 35
7.1 Bibliography 35
7.2 Abbreviations 39
7.3 Methodology 41
7.4 Forecasting Methodology 41
7.4.1 Number of Prostate Cancer Patients Currently Seeking Treatment 41
7.4.2 Percent Drug-treated Patients 42
7.4.3 Percent Hormone Therapy-Treated Patients 42
7.4.4 General Pricing Assumptions 42
7.4.5 Individual Drug Assumptions 44
7.4.6 Generic Erosion 45
7.5 Physicians and Specialists Included in this Study 45
7.6 Survey of Prescribing Physicians 45
7.7 About the Authors 46
7.7.1 Authors 46
7.7.2 Global Head of Healthcare 46
7.8 About GlobalData 47
7.9 Contact Us 47
7.10 Disclaimer 47

Table 1: Stage Distribution of Prostate Cancer at Diagnosis in Selected Major Markets 11
Table 2: Global Variations in Recommendations on Routine PSA Screening 13
Table 3: Most Commonly Followed Treatment Guidelines for Prostate Cancer, 2012 16
Table 4: Most Commonly Prescribed Drugs for Prostate Cancer by Class in the Global Markets, 2012 18
Table 5: Leading Treatments for Prostate Cancer, 2012 28
Table 6: Product Profile - Xtandi 30
Table 7: Xtandi SWOT Analysis, 2012 33
Table 8: Global Sales Forecasts ($m) for Xtandi, 2012-2022 34
Table 9: Physicians Surveyed, By Country 45
Figure 1: General Treatment Algorithm for Prostate Cancer, 2012 17