Strategic Development of Neural Stem & Progenitor Cell Products


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Overview: Neurogenesis is the process by which neurons are created. This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain. Neural stem cells (NSCs) are the self-renewing, multipotent cells that differentiate into the main phenotypes of the nervous system. These cell types include neurons, astrocytes, and oligodendrocytes. Neural progenitor cells (NPCs) are the progeny of stem cell division that normally undergo a limited number of replication cycles in vivo. 

The terms neuronal and neural also need to be defined. Technically speaking, “neuronal” means “pertaining to neurons”, and “neural” means “pertaining to nerves, which are the cordlike bundles of fibers made up of neurons.” Since both terms ultimately are descriptive of neurons, the scientific community uses the terms "neuronal" and "neural" interchangeably. The complexity of this issue is explored from a marketing perspective within this report. 

In 1992, Reynolds and Weiss were the first to isolate neural stem cells from the striatal tissue of adult mice brain tissue, including the subventricular zone, which is a neurogenic area. Since then, neural progenitor and stem cells have been isolated from various areas of the adult brain, including non-neurogenic areas like the spinal cord, and from other species, including humans. During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate. 

Over the past few years, neuronal stem and progenitor cells have become of profound interest to the research community due to their potential to be used in drug discovery and delivery applications, as well as for tools of neural toxicology assessment. NSC transplantation also represents a ground-breaking approach for treating a range of chronic neurological diseases and acute CNS injuries, including Parkinson's, Alzheimer's and spinal cord injury, among other conditions. 

This market report focuses on recent advances in NSC research applications, explores research priorities by market segment, highlights individual labs and end-users of neuronal stem cell research products, explores the competitive environment for NSC research products, and provides 5-year growth and trend analysis. It provides detailed guidance for companies that wish to offer strategically positioned NSC research products, including cells, kits, assays, and related media and reagents. 

This market report includes:

  • Recent advances in NSC research applications
  • Research priorities by market segment
  • Competitive analysis of NSC research supply companies 
  • Segmentation of existing NSC products
  • Individual labs and end-users of NSC research products
  • Patent analysis
  • Overview of specialty pharmaceutical companies developing NSC therapies
  • 5-year market growth projections and trend analysis 
Detailed guidance for companies that wish to offer strategically positioned NSC research products, including cells, kits, assays, media and reagents
TABLE OF CONTENTS 

I. BACKGROUND
A. Language and Definitions
1. Neurogenesis
2. Neuronal vs. Neural 
3. Neural Stem Cells (NSCs) vs. Neural Progenitor Cells (NPCs)
B. Brief History
C. Overview of Neural Stem and Progenitor Cell Regulation
1. In vitro Regulation
2. In vivo Regulation
D. Product Background

II. APPLICATIONS
A. Basic Research
1. Developmental Biology
2. Adult Biology
B. Drug Discovery Applications
C. Drug Delivery Applications 
D. Neural Toxicology Assessment
E. Neural Transplantation
F. Brain Tumor Research

III. APPLICATION PRIORITIES
A. Overall
1. Cell-Based Therapies
2. Standardized Neural Toxicology Assays
B. Breakdown of Neural Stem Cell Research by Disorder
C. By Segment
1. Academic
2. Biotech
3. Pharma

IV. PATENTS
A. Key Neural Stem and Progenitor Cell Patents
B. Additional US Patents
C  Additional European Patents

V. PROJECTED FIVE-YEAR MARKET GROWTH
A.  Scientific Publication Rate Analysis
B.  Grant Rate Analysis 
C.  Patent Rate Analysis

VI. COMPETITORS: SUPPLIERS OF NEURAL STEM & PROGENITOR CELL PRODUCTS
A.  Millipore, Inc.
B.  STEMCELL Technologies
C.  AlphaGenix, Inc. 
D.  R&D Systems
E.  Cell Applications
F.  SA Biosciences
G.  ScienCell
H.  Neuromics
I.  Amaxa
J.  Invitrogen Brand (Life Technologies)
K.  Sigma Aldrich 
L.  Orion (no longer in existence)

VII. SPECIALTY PHARMACEUTICAL COMPANIES PRODUCING 
NEURAL STEM CELL THERAPIES
A. Neuralstem, Inc
B. NeuroNova AB
C. NeuroGeneration

VIII. BREAKDOWN OF STEM CELL RESEARCH ACTIVITY BY CELL TYPE

IX. POTENTIAL END-USERS OF NEURAL STEM CELL PRODUCTS
A. Academic Labs 
B. Private Labs
C. Commercial Labs
D. Government Labs

X. PRODUCT IDEAS & SUGGESTIONS
A. Product Categories
1. Cells & Tissue
a. Fetal-Derived Neural Stem Cells 
b. Adult-Derived Neural Stem Cells 
c. Fetal-Derived Immortalized Neural Stem Cells 
d. Cryopreserved Embryonic Neurospheres
e. Embryonic Stem Cell Derived Neural Progenitors
f. Embryonic Primary Neuronal Tissue 
g. NSC Differentiated Progeny Cells
2. Kits 
a. Kits for Analysis of NSC Differentiated Progeny 
b. Stem Cell Functional Kits 
c. Neuronal Stem Cell Phenotyping Kits
d. Neural Stem Cell Expansion Kits 
e. Neural Stem Cell Differentiation Kits 
f. Neural Stem Cell Blotting Kits
3. Media: Maintenance, Differentiation, Expansion, & Freezing Medium 
4. Growth Factors
5. Markets: Markers for Neural Stem Cells & Differentiated Progeny
6. PCR Arrays
7. Nucleofection Tools
8. Neural Toxicity Assessment
B. Product Suggestions
1. Neural Toxicity Assessment Products 
2. Species-Specific Opportunities
3. Areas of Underdeveloped Competition
4. NSCs Derived from Novel Sources
5. Neural Rosette Cells (R-NSCs) 

XI. CONCLUSIONS