Global & Usa Cancer Immunotherapy Market Analysis To 2020: Antibody Drug Conjugates (ADCs), Bispecific Monoclonal Antibodies, Cancer Vaccines, Cytokines, Interferons, Chimeric Antigen Receptor (CAR) T-Cell Therapy, PD-1/PD-L1 inhibitors, Dendritic Cells


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This report provides a comprehensive overview of the size of cancer immunotherapy market, the segmentation of the market, key players and the vast potential of therapies that are in clinical trials. Oncologic therapeutics cannot cure cancer and yet in 2014, the overall market for cancer therapeutics stood at about $84.3 billion. Any drug that can provide a reasonable survival of more than five years for the cancer patients can achieve a blockbuster status. Within the cancer therapeutics, the immunotherapeutic drugs have gained worldwide acceptance, because they are targeted drugs targeting only the cancer cells. Today, cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market, generating about $41.0 billion in 2014 alone. This report describes the evolution of such a huge market in 11 chapters supported by 114 tables and 41 figures over 256 pages.
  • An overview of cancer immunotherapy that includes: monoclonal antibodies, cancer vaccines and non-specific cancer immunotherapies.
  • Focus on current trends in cancer immunotherapies that include: anti-PD-1 drugs, Dendritic cell vaccines, T-cell therapies and cancer vaccines.
  • Insight into the challenges faced by drug developers, particularly about the success vs. failure ratios in developing cancer immunotherapy drugs.
  • Descriptions about 23 cancer immunotherapeutics approved and used as targeted drugs (some of these products have already been withdrawn from the market).
  • Insight into the various immunotherapeutics available for specific cancer types.
  • Description and data for the prevalence of cancer types that are addressed by cancer immunotherapeutics.
  • Overall global cancer therapeutics market, leading market players and the bestselling cancer drugs.
  • Detailed account of the market for cancer immunotherapeutics by geography, indication, company and individual drugs.
  • Profiles, marketed products and products in pipeline of 76 companies that are mostly located in the U.S. and Europe.
  • Summary table to identify the category of immunotherapy drug offered by the 76 companies.
The report is supported by 155 tables & figures over 246 pages. This report is presented as follows: 

The global market for cancer immunotherapy by the following sub-categories are presented:
  • By Segment (Monoclonal Antibodies, Cancer Vaccines, Non-Specific Therapies, Checkpoint Inhibitors)
  • By Product Segment (Antibody Drug Conjugates (ADCs), Bispecific Monoclonal Antibodies, Cytokines, Interferons, Chimeric Antigen Receptor (CAR) T-Cell Therapy, PD-1/PD-L1 inhibitors, Dendritic Cells, Adopted Cell Therapy (ACT) & IDO Inhibitors
  • By Company (e.g Amgen, Merck, Eli Lilly, GlaxoSmithKline, Janssen, Genentech, Roche, Bristol Myers Squibb)
A comprehensive account of company product portfolios are provided for 78 Cancer Immunotherapy pharma and biotech companies including:
  • Amgen Inc.
  • Biogen Idec Inc.x
  • Bristol-Myers Squibb Co.
  • Cellectis
  • Cellerant Therapeutics Inc.
  • Celldex Therapeutics
  • Eli Lilly and Co.
  • EMD Serono Inc.
  • Genentech Inc.
  • Genmab AS
  • GlaxoSmithKline
  • ImmunoGen Inc.
  • Immunomedics Inc.
  • Janssen Biotech Inc.
  • Juno Therapeutics Inc.
  • Merck & Co., Inc.
  • Oxford BioTherapeutics Ltd.
  • Progenics Pharmaceuticals Inc.
  • Roche Holdings Inc.
  • Seattle Genetics Inc.
  • Sorrento Therapeutics Inc.
Key Questions Answered in this Report
  • What are the three types of cancer immunotherapies?
  • What are the immunotherapies approved between 1986 and 2014?
  • What are the monoclonal antibodies (MAbs) approved by FDA to treat different types of cancers?
  • What are naked MAbs and how many of them have been approved by FDA?
  • What are antibody-drug conjugates (ADCs) and how many of them are available in the market?
  • What are the common cytotoxic “warheads” used in ADCs?
  • What are the important clinical assets in ADCs?
  • How many bispecific MAbs are in late-stage development?
  • What are the common side effects of MAbs in cancer immunotherapy?
  • What are cancer vaccines and how many of them have been licensed to be marketed?
  • How many cytokines have been approved for being used in cancer immunotherapy?
  • What are the major checkpoint inhibitors in clinical development?
  • What is the current status of anti-PD-1 drugs, dendritic cell therapies, T-cell therapies and cancer vaccines?
  • What are the most valuable R&D projects in cancer immunotherapy and what would be their approximate sales revenues in 2020?
  • Number of melanoma drugs approved between 1998 and 2014?
  • Number of lung cancer drugs approved between 1998 and 2014?
  • Number of brain cancer drugs approved between 1998 and 2014?
  • What is the global market for cancer immunotherapeutics by geography, through 2020?
  • What is the global market for cancer immunotherapeutics by product class such as MAbs, vaccines and non-specific immunotherapies, through 2020?
  • What is the global market for cancer immunotherapeutics by indication, through 2020?
  • What is the global market for MAbs by type such as naked MAbs and ADCs, through 2020?
  • What are the market values for Herceptin, Avastin, Erbitux, Yervoy, Mabthera, Adectris, and Keytruda?
  • What is the global market for cancer vaccines?
Table of Content

1.0 Executive Summary
1.1 Objectives of Report
1.1 Key Questions Answered in this Report
1.2 Data Sources and Methodology

2.0 Cancer Immunotherapy: An Overview
2.1 Human Immune System
2.1.1 Components of Human Immune System
2.2 Types of Cancer Immunotherapy
2.3 Monoclonal Antibodies (Mabs) to Treat Cancer
2.3.1 Most Frequently Targeted Antigens by MAbs
2.4 Types of Monoclonal Antibodies (MAbs)
2.4.1 Naked MAbs
2.4.2 Conjugated Monoclonal Antibodies
2.4.2.1 Components of an Antibody Drug Conjugate (ADC)
2.4.2.2 Mechanism of Action of Antibody Drug Conjugate (ADC)
2.4.2.3 The Cytotoxic Warheads used in ADCs
2.4.2.4 Successful Cytotoxin Warheads
2.4.2.5 Developmental Timeline of ADCs
2.4.2.6 Target Antigens for ADCs in Preclinical and Clinical Development
2.4.2.7 Important Clinical Assets in ADCs
2.4.3 Bispecific Monoclonal Antibodies
2.4.3.1 Technology Platforms for the Production of Bispecific MAbs
2.4.4 Safety and Side Effects of MAbs in Cancer Immunotherapy
2.5 Cancer Vaccines
2.5.1 Cancer Vaccines in Development
2.6 Non-Specific Cancer Immunotherapies and Adjuvants
2.6.1 Cytokines
2.6.1 Interferon (IFN)
2.7 New Frontiers in Cancer Immunotherapy Research
2.7.1 Drugs for Targeting Immune Checkpoints
2.7.1.1 Cytotoxic T-Lymphocyte-Associated Protein-4 (CTLA-4)
2.7.1.2 Programmed Death 1 (PD-1) and Programmed Death Ligand 1 (PD-L1)
2.7.1.3 Major Checkpoint Inhibitors in Clinical Development
2.7.2 Chimeric Antigen Receptor (CAR) T Cell Therapy
2.7.3 Tumor-Infiltrating Lymphocytes (TILs) and Interleukin-2 (IL-2)
2.8 Cancer Immunotherapy: Timeline of Progress

3.0 Current Status of Cancer Immunotherapy: An Overview
3.1 Programmed Death (PD-1) Inhibitors
3.1.1 Important Events and Advantages for Nivolumab in Melanoma Indication
3.1.2 Important Events and Advantages for Nivolumab in Non-Small Cell Lung Cancer
3.1.3 Important Events and Advantages for Nivolumab in Renal Cell Cancer
3.1.4 Nivolumab Studies for Melanoma
3.1.5 Nivolumab Studies for Non-Small Cell Lung Cancer (NSCLC)
3.1.6 Nivolumab Studies for Renal Cell Cancer (RCC)
3.2 MK-3475 (Pembrolizumab)
3.2.1 Important Events and Advantages for MK-3475 in Melanoma
3.2.2 Important Events and Advantages for MK-3475 in NSCLC
3.2.3 Important Events for MK-3475 in RCC
3.3 RG7446 from Roche
3.3.1 Important Events for RG7446 in Melanoma
3.3.2 Important Events and Advantages for RG7446 in NSCLC
3.3.3 Important Event for RG7446 in RCC
3.3.4 RG7446 Studies in NSCLC
3.3.5 RG7446 Studies in RCC
3.3.6 RG7446 Study in RCC
3.4 Pidilizumab from CureTech
3.5 An Overview of Anti-PD-1 Clinical Development
3.5.1 Other Checkpoint Inhibitors in Development
3.6 Studies with Yervoy (Ipilimumab)
3.7 Studies with Tremelimumab
3.8 KAHR-102
3.9 TIM3 Antibody
3.10 BMS-989016
3.11 ImmuTune IMP701 and ImmuFact IMP321
3.12 Dendritic Cell Therapies
3.12.1 Provenge (Sipuleucel-T)
3.12.2 AGS-003 from Argos Therapeutics
3.12.3 DCP-001 from DCPrime
3.12.4 DC-Vax from Northwest Biotherapeutics
3.13 Chimeric Antigen Receptor T-Cells (CAR-T) Therapies
3.13.1 CLT109
3.13.2 Chimeric Antigen Receptors (CAR) Program by Juno
3.13.3 Chimeric Antigen Receptor (CAR) T-Cell Program by Bluebird Bio
3.13.4 UCART19 from Cellectis
3.13.5 Chimeric Immune Receptor (CIR) T-Cells from Abramson Cancer Center
3.13.6 CD19 eACT CAR-T Therapy from Kite Pharma
3.13.7 Autologous CAR-T Program for Breast Cancer from Adaptimmune
3.14 Cancer Vaccines
3.14.1 HyperAcute
3.14.2 MAGE-A3 Antigen-Specific Cancer Immunotherapeutic
3.14.3 ADXS-HPV
3.14.4 IDO Inhibitors
3.14.5 Indoximod and NLG-919 (INCY)
3.14.6 INCB24360 (INCY)
3.14.7 deCellVax (BMSN)
3.15 Miscellaneous Immunotherapies
3.15.1 Contego (Lion Biotechnologies)
3.15.2 TG4010 (Transgene)
3.16 Most Valuable R&D Projects in Cancer Immunotherapy
3.16.1 Nivolumab (Opdivo)
3.16.2 MK-3475
3.16.3 RG7446
3.16.4 Palbociclib
3.16.5 DCVax-L
3.16.6 MEDI4736

4.0 Challenges in Cancer Medicine Research: An Overview
4.1 Years of Failures and Emerging Successes in Melanoma Medicine Research
4.1.1 Future Outlook for Melanoma Drugs
4.2 A New Era for Lung Cancer Medicines
4.2.1 Progresses Made in Lung Cancer Medicine Research
4.2.2 Successes and Failures in Lung Cancer Medicine Development
4.2.3 Future Outlook for Lung Cancer Medicines
4.3 Ray of Hope for Brain Cancer Patients
4.3.1 Progress made for Brain Cancer Treatment in Recent Years
4.3.2 Successes and Failures in Brain Cancer Drug Development

5.0 Cancer Immunotherapeutic Products: An Overview
5.1 I-Labelled Tositumomab (Bexxar)
5.2 Y-Labelled Ibritumomab (Zevalin)
5.3 Alemtuzumab (Campath)
5.4 Adotrastuzumab Emtansine (Kadcyla)
5.5 Bacillus Calmette-Guerin (BCG)
5.6 Bevacizumab (Avastin)
5.7 Brentuximab Vedotin (Adcetris)
5.8 Cetuximab (Erbitux)
5.9 Cervarix
5.10 Denileukin Diftitox (Ontak)
5.11 Gardasil
5.12 Gemtuzumab (Mylotarg)
5.13 Hepatitis B Vaccine
5.14 Interferon Alfa (IFN-alfa)
5.15 Interleukin-2 (IL-2)
5.16 Ipilimumab (Yervoy)
5.17 Ofatumumab (Arzerra)
5.18 Panitumumab (Vectibix)
5.19 Pembrolizumab (Keytruda)
5.20 Rituximab (Mabthera)
5.21 Sargramostim (Leukine)
5.22 Sipuleucel-T (Provenge)
5.23 Trastuzumab (Herceptin)

6.0 Available Immunotherapies for Cancer by Disease Type: An Overview
6.1 Melanoma Skin Cancer and Immunotherapy
6.1.1 Ipilimumab (Yervoy) for Advanced Melanoma
6.1.2 PD-1 Inhibitors (Keytruda and Opdivo) for Advanced Melanoma
6.1.3 Cytokines for Advanced Melanoma
6.1.4 Interferon Alfa as Adjuvant Therapy for Melanoma
6.1.5 Bacille Calmette-Guerin (BCG) Vaccine for Melanoma
6.1.6 Imiquimod (zyclara) Cream for Melanoma
6.2 Breast Cancer and Immunotherapy
6.2.1 Promising Therapeutic Vaccine Product Candidates for Breast Cancer
6.2.2 Promising Checkpoint Inhibiting Product Candidates for Breast Cancer
6.2.3 Promising Adoptive T Cell Therapy Product Candidates for Breast Cancer
6.2.4 Promising Antibody Product Candidates for Breast Cancer
6.3 Immunotherapy for Prostate Cancer
6.3.1 Therapeutic Vaccines for Prostate Cancer
6.3.2 Checkpoint Inhibitors for Prostate Cancer
6.3.3 Adoptive Cell Therapy for Prostate Cancer
6.4 Immunotherapy for Lung Cancer
6.4.1 Monoclonal Antibodies for Lung Cancer
6.4.1.1 Promising MAb Product Candidates for Lung Cancer
6.4.1.2 Checkpoint Inhibitors for Lung Cancer
6.4.1.3 Therapeutic Vaccines for Lung Cancer
6.4.1.4 Promising Adoptive T Cell Transfer Product Candidates for Lung Cancer
6.5 Immunotherapy for Colorectal Cancer
6.5.1 Promising Monoclonal Antibody Product Candidates for Colorectal Cancer
6.5.2 Trials Using Checkpoint Inhibitors and Immune Modulators for Colorectal Cancer
6.5.3 Clinical Trials for Vaccines Indicated for Colorectal Cancer
6.5.4 Adoptive Cell Therapy for Colorectal Cancer
6.5.5 Oncolytic Virus Therapy for Colorectal Cancer
6.5.6 Adjuvant Immunotherapy for Colorectal Cancer
6.5.7 Cytokines for Colorectal Cancer
6.6 Immunotherapies in Development for Lymphoma
6.6.1 Therapeutic Vaccines in Development for Lymphoma
6.6.2 Checkpoint Inhibitors for Lymphoma
6.6.3 Adoptive T Cell Transfer for Lymphoma
6.6.4 Monoclonal Antibodies for Lymphoma
6.7 Immunotherapy for Kidney Cancer
6.7.1 Checkpoint Inhibitors for Kidney Cancer
6.7.2 Vaccines for Kidney Cancer
6.7.3 Adoptive Cell Therapy for Kidney Cancer
6.8 Dominance of MAbs and Vaccines in Cancer Clinical Research
6.9 Oncology Biologics Losing Patent Protection

7.0 Cancer Incidence and Mortality: An Overview
7.1 Global Economic Burden of Cancer
7.2 Global Burden of Cancer
7.3 Top Five Most Frequent Cancers, Globally
7.3.1 Global Prevalence of Colorectal, Breast and Lung Cancers
7.3.2 Percentage of Top Three Cancers Diagnosed Globally
7.3.2.1 Mortality due to Lung, Liver and Stomach Cancers
7.3.2.2 Percentage of Death due to Lung, Liver and Stomach Cancers
7.4 Cancer Deaths in Women
7.5 Prevalence and Mortality for Cancer Types Addressed by Immunotherapy
7.5.1 Breast Cancer
7.5.1.1 Worldwide Incidence of Breast Cancer and Mortality Rate by Geography
7.5.1.2 Female Breast Cancer Incidence in the U.S.
7.5.1.3 Five Year Breast Cancer Survival Rates by Stage at Diagnosis and Age in the U.S.
7.5.1.4 Breast Cancer Incidence in Canada
7.5.1.5 Breast Cancer Incidence and Mortality in Latin America
7.5.1.6 Breast Cancer Incidence and Mortality in Europe
7.5.1.7 Breast Cancer Incidence in Asia/Pacific
7.5.1.8 Breast Cancer Incidence by Country
7.5.2 Gastric Cancer (Stomach Cancer)
7.5.2.1 Incidence of Gastric Cancer in Top 15 Countries
7.5.3 Colorectal Cancer
7.5.3.1 Global Incidence of Colorectal Cancer
7.5.3.2 Worldwide Variations in the Incidence of Colorectal Cancer
7.5.3.3 Risk Factors for Colorectal Cancer
7.5.3.4 Colorectal Cancer Screening in the U.S.
7.5.3.5 Colorectal Cancer Incidence Rates in the U.S. by State
7.5.3.6 Colorectal Cancer Mortality Rates (per 100,000) in the U.S. by States
7.5.4 Lung Cancer
7.5.4.1 Non-Small Cell Lung Cancer (NSCLC)
7.5.4.2 Global NSCLC Incidence
7.5.4.3 Lung Cancer in Americas by Gender
7.5.4.4 Tobacco Use and Lung Cancer
7.5.4.5 Current Therapeutic Options for Lung Cancer
7.5.5 Glioblastoma
7.5.5.1 Global Incidence of Glioblastoma
7.5.6 Kidney Cancer
7.5.6.1 Global Incidence of Kidney Cancer
7.5.7 Blood Cancer
7.5.7.1 Leukemia
7.5.7.2 Blood Cancer in the U.S.
7.5.8 Cervical Cancer
7.5.8.1 Global Incidence of Cervical Cancer
7.5.9 Prostate Cancer
7.5.9.1 Global Incidence of Prostate Cancer
7.5.9.2 Prostate Cancer Incidence and Mortality by Geography
7.5.9.3 Prostrate Cancer in the U.S.
7.5.10 Melanoma
7.5.10.1 Skin Cancer in the U.S.

8.0 Market Analysis
8.1 Global Oncology Market
8.2 Top Ten Companies in Oncology Drug Sales
8.3 Top Five Oncology Drugs
8.4 Global Oncology Therapeutics Market by Cancer Type

9.0 Market for Cancer Immunotherapy
9.1 Key Drivers
9.2 Global Market for Cancer Immunotherapeutics
9.3 Global Market for Cancer Immunotherapy by Product Class
9.4 Global Market for Immunotherapy Drugs by Cancer Type
9.5 Global Market for Monoclonal Antibodies for Cancer by Type
9.5.1 Best Selling MAbs
9.5.1.1 Market Forecast for Herceptin
9.5.1.2 Market Value and Forecast for Avastin
9.5.1.3 Global Market for Erbitux
9.5.1.4 Global Market for Yervoy
9.5.1.5 Global Market for Mabthera
9.5.2 Global Market for Antibody Drug Conjugates (ADCs)
9.5.2.1 MGlobal Market for Adcetris
9.5.2.1 Global Market for Keytruda
9.6 Global Market for Cancer Vaccines
9.6.1 Global Market for Cancer Vaccines by Type
9.7 Global Market for Non-Specific Cancer Immunotherapeutics
9.8 Market Values for Selected Forthcoming Cancer Immunotherapeutics
9.8.1 Market Value for Nivolumab (Opdivo)
9.8.2 Market Value for RG7446
9.8.3 Market Value for DCVax-L
9.8.4 Market Value for MEDI4736
9.8.5 High Cost of MAbs

10.0 Company Profiles
10.1 Ablynx NV
10.2 Activartis Biotech GmbH
10.2.1 GBM Vax Study
10.3 Advaxis Inc.
10.3.1 Advaxis’ Technology
10.3.2 Advaxis’ Product Pipeline
10.3.2.1 ADXS-HPV
10.3.2.2 ADXS-PSA
10.3.2.3 ADXS-cHER2
10.4 Aduro BioTech Inc.
10.4.1 Aduro’s Technology
10.4.1.1 CRS-207
10.4.1.2 AUD-623
10.4.1.3 ADU-741
10.4.1.4 ADU-S100
10.5 Agenus Inc.
10.5.1 QS-21 Stimulon
10.6 AlphaVax Inc.
10.6.1 Alpha Vax’s Technology
10.7 A. Menarini Industrie Farmaceutiche Riunite Srl
10.7.1 MEN1112
10.8 Amgen Inc.
10.8.1 Vectibix (panitumumab)
10.8.2 Blinatumomab (Blincyto)
10.8.3 Rilotumumab
10.9 Antigen Express Inc.
10.9.1 Li-Key Hybrid Vaccines (AE37)
10.10 Argos Therapeutics Inc.
10.10.1 AGS-003
10.11 Bavarian Nordic A/S
10.11.1 Prostvac
10.11.2 CV-301
10.11.3 MVA-BN PRP
10.11.4 MVA-BN HER2
10.11.4 MVA-BN Brachyury
10.12 Bellicum Pharmaceuticals Inc.
10.12.1 BPX-501
10.12.2 BPX-201
10.12.3 BPX-401
10.12.4 BPX-601
10.12.5 BPX-701
10.13 Biogen Idec Inc.
10.13.1 Rituxan (Rituximab)
10.13.2 Gazyva (Obinutuzumab)
10.14 Biovest International Inc.
10.14.1 BiovaxID
10.15 Bristol-Myers Squibb Company
10.15.1 Erbitux (cetuximab)
10.15.2 OPDIVO (nivolumab)
10.15.3 Yervoy (ipilimumab)
10.16 Cellectis
10.17 Cellerant Therapeutics Inc.
10.17.1 CLT-008
10.17.2 CLT-009
10.18 Celldex Therapeutics
10.18.1 Rindopepimut
10.18.2 Glembatumumab vedotin (CDX-011)
10.18.3 Varlilumab (CDX-1127)
10.18.4 CDX-1401
10.18.5 CDX-301
10.19 CEL-SCI Corp.
10.19.1 Multikine
10.20 CureTech Ltd.
10.20.1 Pidilizumab (CT-011)
10.21 Delta-Vir GmbH
10.21.1 Treatment
10.22 Dendreon Corp.
10.22.1 Provenge (Sipuleucel-T)
10.23 DenDrit Biotech USA
10.23.1 MelCancerVac
10.24 DNAtrix Inc.
10.24.1 DNX-2401
10.25 Eli Lilly and Co.
10.25.1 Erbitux (Cetuximab)
10.26 EMD Serono Inc.
10.27 Etubics Corp.
10.28 Galena Biopharma Inc.
10.29 Genentech Inc.
10.29.1 Avastin (bevacizumab) for Metastatic Colorectal Cancer
10.29.1.1 Avastin and Interferon Alfa for Metastatic Kidney Cancer
10.29.1.2 Avastin for Metastatic NLCLC
10.29.2 Gazyva (obinutuzumab) for Chronic Lymphocytic Leukemia
10.29.3 Herceptin (trastuzumab) for Breast Cancer
10.29.3.1 Herceptin and Chemotherapy for Gastric Cancer
10.29.4 Kadcyla (ado-trastuzumab emtansine)
10.29.5 Perjeta (pertuzumab)
10.29.6 Rituxan (rituximab)
10.29.7 Genentech’s Cancer Immunotherapy Pipeline Products
10.30 Genmab AS
10.30.1 Ofatumumab
10.31 GlaxoSmithKline
10.31.1 Arzerra (Ofatumumab)
10.31.2 Cervarix
10.32 Gliknik Inc.
10.33 GlobeImmune Inc.
10.34 Heat Biologics Inc.
10.35 Immatics Biotechnologies GmbH
10.36 ImmunoCellular Therapeutics Ltd.
10.37 Immunocore Ltd.
10.37.1 Product Pipeline
10.38 ImmunoFrontier Inc.
10.39 ImmunoGen Inc.
10.39.1 IMGN853
10.39.2 IMGN529
10.39.3 IMGN289
10.39.4 IMGN779
10.40 Immunomedics Inc.
10.41 Immunotope Inc.
10.41.1 IMT-1012 Immunotherapeutic Vaccine
10.42 Immunovaccine Inc.
10.43 Inovio Pharmaceuticals Inc.
10.44 Janssen Biotech Inc.
10.44.1 Doxil
10.44.2 Procrit
10.44.3 Zytiga
10.44.4 Imbruvicia
10.45 Juno Therapeutics Inc.
10.46 Kite Pharma Inc.
10.46.1 Kite Pharma’s Technology
10.46.1.1 eACT (engineered Autologous Cell Therapy)
10.46.1.2 DC-Ad GM-CAIX
10.47 MabVax Therapeutics Holdings Inc.
10.48 MedImmune LLC
10.49 Merck & Co., Inc.
10.49.1 Gardasil (Human Papillomavirus Quadrivalent (Types 6, 11, 16 and 18) Vaccine
10.49.2 Keytruda (Pembrolizumab)
10.50 Merrimack Pharmaceuticals Inc.
10.51 Morphotek Inc.
10.51.1 Farletuzumab (MORAb-003)
10.51.2 Amatuximab (MORAb-009)
10.51.3 Ontuxizumab (MORAb-004)
10.51.4 MORAb-066
10.52 NewLink Genetics Corp.
10.53 Northwest Biotherapeutics Inc.
10.54 NovaRx Corp.
10.55 OncoPep Inc.
10.55.1 PVX-410
10.56 Oncothyreon Inc.
10.57 OSE Pharma SA
10.58 Oxford BioTherapeutics Ltd.
10.58.1 Technologies
10.58.1.1 OGAP – Cancer Targeting
10.58.1.2 Antibody Development
10.58.1.3 Antibody “arming”
10.58.2 Lead Programs
10.58.2.1 OX001/MEN1112
10.58.2.2 OX002
10.58.2.3 OX003
10.58.2.4 OX004
10.59 Pique Therapeutics
10.60 Polynoma LLC
10.60.1 MAVIS Trial
10.61 Prima BioMed Ltd.
10.62 Progenics Pharmaceuticals Inc.
10.62.1 PSMA Targeted Imaging Compound (1404)
10.62.2 PSMA ADC Therapeutic
10.62.3 Small Molecule Therapeutic (1095)
10.62.4 Azedra
10.63 Regen Biopharma Inc.
10.63.1 HemaXellerate
10.63.2 dCellVax
10.63.3 Diffron C
10.64 Roche Holdings Inc.
10.64.1 Avastin (Bevacizumab)
10.64.2 Gazyva/Gazyvaro (Obinutuzumab; GA101)
10.64.3 Herceptin (Trastuzumab)
10.64.4 Kadcyla (Trastuzumabum emtansinum)
10.64.5 Mabthera (Rituximab)
10.64.6 Perjeta (Pertuzumab)
10.65 Seattle Genetics Inc.
10.65.1 Adcetris (Brentuximab vedotin)
10.65.2 Seattle Genetics’ Collaborarator Pipeline
10.66 Sorrento Therapeutics Inc.
10.66.1 Sorrento’s Antibody Technologies
10.66.1.1 G-MAB
10.66.1.2 Antibody Drug Conjugates (ADCs)
10.67 Spectrum Pharmaceuticals Inc.
10.67.1 Zevalin
10.68 Synthon Pharmaceuticals Inc.
10.69 TapImmune Inc.
10.70 ThioLogics Ltd.
10.71 Transgene SA
10.72 TVAX Biomedical Inc.
10.72.1 TVI-Brain-1
10.72.2 TVI-Kidney-1
10.73 Vaccinogen Inc.
10.74 Viventia Biotechnologies Inc.
10.75 Wilex AG
10.76 Ziopharm Oncology Inc.

11.0 Cancer Immunotherapy Market Participants by Product Segment

Table 2.1: Types of Immune Cells and their Functions
Table 2.2: FDA-Approved Cancer Immunotherapies, 1986-2014
Table 2.3: FDA-Approved Monoclonal Antibodies (MAbs) to Treat Cancer
Table 2.4: Most Frequently Targeted Antigens by MAbs
Table 2.5: FDA-Approved Monoclonal Antibodies
Table 2.6: Cytotoxic Warheads Used in ADCs
Table 2.7: Targeted Indications for ADCs
Table 2.8: Antibody Drug Conjugates: Developmental Tmeline
Table 2.9: Target Antigens for ADCs in Preclinical and Clinical Development
Table 2.10: Current ADCs Launched, Withdrawn and in Phase I/II/III Trials by Sponsor, Indication, Antigen, Cytotoxin and Linker
Table 2.11: MAb Products and Candidates that Recruit T Cells
Table 2.12: Bispecific MAbs in Clinical Trials Targeting Cancer by Indication and Company
Table 2.13: Bispecific Antibody Technology Platforms
Table 2.14: Side Effects of Some of the Approved Cancer Immunotherapy MAbs
Table 2.15: FDA-Approved Cancer Vaccines
Table 2.16: Cancer Vaccines in Development
Table 2.17: FDA-Approved Cytokines for Cancer Immunotherapy
Table 2.18: Cancer Indications Approved for IFN-alfa
Table 2.19: FDA-Approved Immune Checkpoint Modulators
Table 2.20: Immune Checkpoint Inhibitors in Clinical Development
Table 2.21: Cancer Immunotherapy: Timeline of Progress
Table 3.1: PD-1 Therapies Targeting either the PD-L1/L2 or PD-1 Receptor
Table 3.2: Overview of Clinical Trial Landscape for Top Five Anti-PD-1 and Anti-PD-L1 Dru
Table 3.3: Nivolumab Efficacy from Expansion Coharts of Study 003
Table 3.4: Phase I Data of MK-3475 in Melanoma
Table 3.5: Phase I Data of RG7446 in NSCLC Patients
Table 3.6: RG7446 Phase I Data from RCC Patients
Table 3.7: Phase I Melanoma Data for RG7446
Table 3.8: Phase II Data for Pidilizumab in Diffuse Large B Cell Lymphoma (DLBCL)
Table 3.9: Phase II Melanoma Data for Pidilizumab
Table 3.10: An Overview of Anti-PD-1 Development by Company, Drug Candidate, Indication and Clinical Phase
Table 3.11: Clinical Development of CTLA-4, TIM3, and LAG3 Checkpoint Inhibitors by Company, Drug Candidate, Indication and Clinical Trial Stage
Table 3.12: Pivotal Phase III Results for Yervoy in Second-Line Patients with Metastatic Melanom
Table 3.13: Updated Data from Phase III Clinical Study 024 for Yervoy
Table 3.14: Data from the Failed Phase III Study of Tremelimumab for Melanoma
Table 3.15: An Overview of Clinical Development of Dendritic Cell Therapies by Company, Drug Candidate, Indication and Clinical Phase
Table 3.16: Pivotal Phase III Rwesults for Yervoy in Second-Line Patients with Metastatic Melanoma
Table 3.17: Phase I/Iia Results from Kite Pharma’s CAR-T Therapy
Table 3.18: Cancer Vaccines in Development by Company, Drug Candidate, Indication and Clinical Phase
Table 3.19: Advaxis Phase II Results for Cervical Cancer Patients in India
Table 3.20: Phase II Data for Contego
Table 3.21: Valuable R&D Projects in Cancer Immunotherapy
Table 6.1: Cancer Types Addressed by Immunotherapies by Drug, Trade Name and Company
Table 6.2: Oncology Drugs Losing Patent Protection by 2020 by Product, U.S. Expiry Date and E.U. Expiry Date
Table 7.1: Global Cancer Statistics – Key Facts
Table 7.2: Top Five Most Frequent Cancers, Globally
Table 7.3: Estimated Breast Cancer Cases and Deaths in the U.S. by Age, 2013
Table 7.4: Estimated Canadian Breast Cancer Statistics for 2014
Table 7.5: Age-Standardized Breast Cancer Incidence Rate per 100,000 Women by Country
Table 7.6: Global Colorectal Cancer Incidence and Mortality Rates by Gender per 100,000 people
Table 7.7: Risk Factors for Colorectal Cancer
Table 7.8: Lung Cancer Incidence and Mortality Rate in Americas by Gender
Table 7.9: Current Therapeutic Options for Lung Cancer
Table 7.10: Estimated Number of New Leukemia Cases in the U.S., 2014
Table 7.11: Estimated Deaths in the U.S. from Leukemia, 2014
Table 7.12: Estimated Deaths from HL and NHL in the U.S., 2014
Table 7.13: Estimated Incidence and Deaths for Myeloma in the U.S., 2014
Table 7.14 Global Prostate Cancer Incidence and Mortality Rates by Geography
Table 7.15: Incidence and Mortality Rates of Prostate Cancer in Americas
Table 7.16: Incidence and Mortality Rates for Melanoma in Americas
Table 8.1: Global Market for Oncology Drugs by Geography/Country, Through 2020
Table 8.2: Top Ten Companies in Oncology Sales, Through 2020
Table 8.3: Top Five Oncology Drugs, Through 2020
Table 9.1: Global Cancer Immunotherapy Market, Through 2020
Table 9.2: Global Market for Immunotherapy by Product Class, Through 2020
Table 9.3: Global Market for Immunotherapy Drugs by Cancer Type, Through 2020
Table 9.4: Global Market for Monoclonal Antibodies for Cancer by Type, Through 2020
Table 9.5: Global and U.S. Market for Herceptin, Through 2020
Table 9.6: Global and U.S. Market for Avastin, Through 2020
Table 9.7: Global Market for Cancer Vaccines, Through 2020
Table 9.8: Global Market for Cancer Vaccines by Type, Through 2020
Table 9.9: Projected Market for the Forthcoming Nivolumab, RG7446, DCVax-L and MEDI4736
Table 9.10: Annual Cost of MAbs in the U.S. by Product, Indication and Biomarker
Table 10.1: Ablynx’s Product Pipeline
Table 10.2: Aduro’s Product Pipeline
Table 10.3: Agenus’ Product Pipeline
Table 10.4: AlphaVax Cancer Immunology Product Pipeline
Table 10.5: Amgen’s Product Pipeline
Table 10.6: Antigen Express’ Cancer Therapeutic Pipeline
Table 10.7: Argos’ Cancer Product Pipeline
Table 10.8: Bavarian Nordic’s Product Pipenine
Table 10.9: Bellicum’s Pipeline Product Candidatea
Table 10.10: Biogen’s Oncology Pipeline
Table 10.11: Bristol-Myers Squibb’s Pipeline Products in Cancer Immunotherapy
Table 10.12: Cellectis’ Products in Development
Table 10.13: Cellerant’s Product Pipeline
Table 10.14: Celldex’s Therapeutic Pipeline
Table 10.15: CEL-SCI’s Immunotherapy Products in Development
Table 10.16: EMD Serono’s Product Pipeline
Table 10.17: Etubic’s Product Pipeline
Table 10.18: Galena’s Product Pipeline
Table 10.19: Genentech’s Cancer Immunotherapy Pipeline Products
Table 10.20: Genmab’s Products in Development
Table 10.21: Gliknik’s Product Pipeline
Table 10.22: GlobeImmune’s Product Pipeline
Table 10.23: Heat Biologic’s Product Pipeline
Table 10.24: Immatics Biotechnology’s Product Pipeline
Table 10.25: ImmunoCellular’s Product Pipeline
Table 10.26: Immunomedics’ Late-Stage Antibody-Based Therapies
Table 10.27: Immunovaccine’s Product Pipeline
Table 10.28: Inovio Pharmaceuticals Product Pipeline
Table 10.29: Juno Therapeutics’ Current Pipeline
Table 10.30: Kite Pharma’s Product Pipeline
Table 10.31: MabVax’s Product Pipeline
Table 10.32: MedImmune’s Products in Development
Table 10.33: Merck’s Pipeline of Cancer Immunotherapy Products
Table 10.34: Merrimack’s Product Pipeline
Table 10.35: NewLink Genetics’ Product Pipeline
Table 10.36: Northwest’s Product Pipeline
Table 10.37: NovaRx Clinical Development Pipeline
Table 10.38: Oncothyreon’s Immunotherapy Product Pipeline
Table 10.39: OSE Pharma’s Product Pipeline
Table 10.40: Pique Therapeutics’ Product Pipeline
Table 10.41: Prima BioMed’s Pipeline
Table 10.42: Progenics Pharmaceutical’s Pipeline
Table 10.43: Roche Holding’s Cancer Immunotherapy Product Pipeline
Table 10.44: Seattle Genetics’ Pipeline Products
Table 10.45: Seattle Genetics’ Collaborarator Pipeline
Table 10.46: Synthon Biopharmaceuticals’ Pipeline
Table 10.47: TapImmune’s Product Pipeline
Table 10.48: ThioLogic’s Product Pipeline
Table 10.49: Transgene’s Product Pipeline
Table 10.50: Vaccinogen’s Product Pipeline
Table 10.51: Viventia’s Product Pipeline
Table 10.52: Wilex’s Product Pipeline
Table 10.53: Ziopharm’s Products in Development
Table 11.1: Cancer Immunotherapy Market Participants by Product Segment
Figure 2.1: Components of an Antibody Drug Conjugate (ADC)
Figure 2.2: Mechanism of Action of Antibody Drug Conjugates
Figure 2.3: Ranking of Commonly Used Cytotoxin Warheads
Figure 4.1: Number of Successful and Unsuccessful Melanoma Drugs, 1998-2014
Figure 4.2: Successes and Failures in Lung Cancer Medicine Development, 1998-2014
Figure 4.3: Successes and Failures in Brain Cancer Drug Development, 1998-2014
Figure 5.1: Ibritumomab Linked to Yttrium Radfionucleotide
Figure 5.2: Kadcyla (Trastuzumab + DMI)
Figure 6.1: Dominance of MAbs and Vaccines in Cancer Clinical Research
Figure 7.1: Global Economic Burden of Cancer
Figure 7.2: Number of Colorectal, Breast and Lung Cancer Cases Diagnosed Globally, 2012
Figure 7.3 Percentage of Top Three Cancers Diagnosed Globally, 2012
Figure 7.4: Number of Deaths due to Lung, Liver and Stomach Cancers Globally, 2012
Figure 7.5: Percentage of Deaths due to Lung, Liver and Stomach Cancers, 2012
Figure 7.6: Global Cancer Deaths in Women by Type of Cancer
Figure 7.7: Worldwide Incidence of Female Breast Cancer and Mortality Rate by Geography
Figure 7.8: Five Year Relative Breast Cancer Survival Rates by Stage at Diagnosis and Age in theU.S.
Figure 7.9: Breast Cancer Incidence and Mortality in Latin America
Figure 7.10: Breast Cancer Incidence and Mortality in Europe
Figure 7.11: Breast Cancer Incidence Rates in Asia/Pacific Region
Figure 7.12: Top 15 Countries in Gastric Cancer Incidence
Figure 7.13: Top 15 Countries in Colorectal Cancer Incidence
Figure 7.14: Adults Aged 50-75 Years (%) That are Up-to-Date with Colorectal Screening Tests by State in the U.S.
Figure 7.15 Colorectal Cancer Incidence Rates (per 100,000) by State in the U.S.
Figure 7.16: Colorectal Cancer Mortality Rates (per 100,000) in the U.S. by States
Figure 7.17: Top 15 Countries with Lung Cancer
Figure 7.18: Global NSCLC Incidence
Figure 7.19: Number of Smokers in China, India, Russia, the U.K. ans U.S.
Figure 7.20: Global Incidence of Glioblastoma
Figure 7.21: Global Incidence of Kidney Cancer
Figure 7.22: Top 15 Countries in Leukemia Mortality
Figure 7.23: Five Year Survival Rates in the U.S. for Blood Cancer Patients
Figure 7.24 Top 15 Countries in Cervical Cancer
Figure 7.25: Top 15 Countries with Prostate Cancer
Figure 7.26: Skin Cancer Death Rates for Top 15 Countries
Figure 8.1: Global Market for Oncology Drugs by Geography/Country, Through 2020
Figure 8.2: Global Oncology Drug Sales by Top Five Companies, Through 2020
Figure 8.3: Top Five Oncology Drugs, Through 2020
Figure 8.4: Global Oncology Therapeutics Market by Cancer Type, 2014
Figure 9.1: Global Cancer Immunotherapy Market, Through 2020
Figure 9.2: Global Market for Immunotherapy by Product Class, Through 2020
Figure 9.3: Global Market for Immunotherapy Drugs by Cancer Type, Through 2020
Figure 9.4: Global Market for Monoclonal Antibodies for Cancer by Type, Through 2020
Figure 9.5: Global and U.S. Market for Herceptin, Through 2020
Figure 9.6: Global and U.S. Market for Avastin, Through 2020
Figure 9.7: Global Market for Erbitux, Through 2020
Figure 9.8: Global Market for Yervoy, Through 2020
Figure 9.9: Global Market for Mabthera, Through 2020
Figure 9.10: Global Market for Adcetris, Through 2020
Figure 9.11: Global Market for Keytruda, Through 2020
Figure 9.12: Global Market for Cancer Vaccines, Through 2020
Figure 9.13: Global Market for Cancer Vaccines by Type, Through 2020
Figure 9.14: Global Market for Cytokine Drugs for Cancer, Through 2020