EpiCast Report: Heart Failure - Epidemiology Forecast to 2025


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77pages

GlobalData

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EpiCast Report: Heart Failure - Epidemiology Forecast to 2025

Summary

Heart Failure (HF), also referred to as congestive cardiac failure, is a heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic needs of the body. Eventually, without the heart's pumping action to deliver oxygen and nutrient-rich blood to the cells, fatigue, shortness of breath, and coughing results. HF commonly occurs in people above 50 years of age, and severity increases progressively with age. Symptoms can develop quickly, such as in acute HF, at which time the patient needs to be hospitalized. However, in chronic HF, the symptoms develop gradually. Due to the chronic nature of cardiovascular diseases, many of the risk factors for HF, such as chronic obstructive pulmonary disease (COPD) and anemia, are also comorbid conditions.

In the 7MM, GlobalData epidemiologists forecast that the diagnosed incident cases of HF will increase from 1,094,344 cases in 2015 to 1,400,377 cases in 2025 at an Annual Growth Rate (AGR) of 2.80%. In the 7MM, GlobalData epidemiologists forecast that the diagnosed prevalent cases of chronic HF will increase from 13,756,453 cases in 2015 to 16,105,489 cases in 2025 at an AGR of 1.71%. The US will have the highest number of diagnosed incident cases of HF and diagnosed prevalent cases of chronic HF among the 7MM throughout the forecast period with 1,052,831 diagnosed incident cases of HF and 6,170,142 diagnosed prevalent cases of chronic HF in 2025. In the 7MM in 2015, 37.59% of the diagnosed prevalent cases of chronic HF are in NYHA Class I, 39.54% in NYHA Class II, 19.11% in NYHA Class III, and 3.75% in NYHA Class IV.

GlobalData epidemiologists utilized comprehensive, country-specific data from national HF registers and peer-reviewed journal articles to arrive at a meaningful, in-depth analysis and forecast for the diagnosed incident cases of HF, as well as the diagnosed prevalent cases of chronic HF. In this analysis, GlobalData epidemiologists provide detailed, clinically relevant segmentations for diagnosed incident and diagnosed prevalent cases of HF. Finally, the same forecast methodology was used across the 7MM, thereby allowing for meaningful global comparisons of the diagnosed incident and diagnosed prevalent cases of HF across these markets.

Scope

- The Heart Failure (HF) EpiCast Report provides an overview of the risk factors and global trends of HF in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan). It includes a 10-year epidemiology forecast of HF diagnosed incident and diagnosed prevalent cases segmented by age and sex. Diagnosed incident cases are further segmented by ejection fraction, ventricular dysfunction, acute HF hospitalizations (by worsening HF, advanced HF, de novo HF), re-admissions (within 3 months) post-discharge after acute HF hospitalization, and hospital length of stay for acute HF hospitalization in these seven markets. Diagnosed prevalent cases are further segmented by chronic HF (by ejection fraction), and also classified according to the New York Heart Association (NYHA) functional classes I-IV, and American College of Cardiology Foundation/American Heart Association (ACCF/AHA) stages B, C and D in these seven markets.
- The HF epidemiology report is written and developed by Masters- and PhD-level epidemiologists.
- The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 7MM.

Reasons to buy

The HF EpiCast report will allow you to -
- Develop business strategies by understanding the trends shaping and driving the global HF market.
- Quantify patient populations in the global HF market to improve product design, pricing, and launch plans.
- Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for HF therapeutics in each of the markets covered.
- Identify the percentage of HF diagnosed incident and diagnosed prevalent cases by various clinical segmentations.
1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 6
1.2 List of Figures 7
2 Epidemiology 9
2.1 Disease Background 9
2.2 Risk Factors and Comorbidities 10
2.3 Global Trends 12
2.3.1 US 12
2.3.2 5EU 13
2.3.3 Japan 14
2.4 Forecast Methodology. 15
2.4.1 Sources Used Tables 17
2.4.2 Forecast Assumptions and Methods 20
2.4.3 Sources Not Used 35
2.5 Epidemiological Forecast for HF (2015-2025) 36
2.5.1 Diagnosed Incident Cases 36
2.5.2 Diagnosed Prevalent Cases 49
2.6 Discussion 61
2.6.1 Epidemiological Forecast Insight 61
2.6.2 Limitations of the Analysis 61
2.6.3 Strengths of the Analysis 62
3 Appendix 63
3.1 Bibliography 63
3.2 About the Authors 72
3.2.1 Epidemiologists 72
3.2.2 Reviewers 72
3.2.3 Global Director of Therapy Analysis and Epidemiology 73
3.2.4 Global Head of Healthcare 74
3.3 About GlobalData 75
3.4 About EpiCast 75
3.5 Disclaimer 76

1.1 List of Tables
Table 1: Risk Factors and Comorbidities for HF 11
Table 2: NYHA Functional Classes I-IV 16
Table 3: ACCF/AHA Stages A, B, C, and D 17
Table 4: 7MM, Sources of Epidemiological Data Used for the Forecast of HF Diagnosed Incident Cases 17
Table 5: 7MM, Sources of Epidemiological Data Used for the Forecast of Chronic HF Diagnosed Prevalent Cases 18
Table 6: 7MM, Sources of Epidemiological Data Used for the Classification of Diagnosed Prevalent Cases of Chronic HF According to the NYHA Functional Classes I-IV 19
Table 7: 7MM, Sources of Epidemiological Data Used for Forecast of HF Diagnosed Incident Cases of Acute HF Hospitalizations 20
Table 8: 7MM, Sources Not Used in Epidemiological Analysis of HF 35
Table 9: 7MM, Diagnosed Incident Cases of HF, Ages 45 Years, Both Sexes, N, 2015-2025 37
Table 10: 7MM, Age-Specific Diagnosed Incident Cases of HF, Both Sexes, N (Row %), 2015 38
Table 11: 7MM, Sex-Specific Diagnosed Incident Cases of HF, Ages 45 Years, N (Row %), 2015 40
Table 12: 7MM, Diagnosed Incident Cases of Acute HF Hospitalizations, Ages 45 Years, Both Sexes, N, 2015-2025 45
Table 13: 7MM, Readmissions (Within Three Months) Post-Discharge After Acute HF Hospitalization Among Diagnosed Incident Cases of Acute HF, Ages 45 Years, Both Sexes, N, 2015-2025 47
Table 14: 7MM, Diagnosed Prevalent Cases of Chronic HF, Ages 45 Years, Both Sexes, N, 2015-2025 50
Table 15: 7MM, Age-Specific Diagnosed Prevalent Cases of Chronic HF, Both Sexes, N (Row %), 2015 52
Table 16: 7MM, Sex-Specific Diagnosed Prevalent Cases of Chronic HF, Ages 45 Years, N (Row %), 2015 54

1.2 List of Figures
Figure 1: 7MM, Diagnosed Incident Cases of HF, Ages 45 Years, Both Sexes, N, 2015-2025 37
Figure 2: 7MM, Diagnosed Incident Cases of HF by Age Group, Both Sexes, N, 2015 39
Figure 3: 7MM, Sex-Specific Diagnosed Incident Cases of HF, Ages 45 Years, N, 2015 41
Figure 4: 7MM, Age-Standardized Diagnosed Incidence of HF (Cases per 100,000 Population), Ages 45 Years, by Sex, 2015 42
Figure 5: 7MM, Diagnosed Incident Cases of HF Segmented by EF, Ages 45 Years, Both Sexes, N, 2015 43
Figure 6: 7MM, Diagnosed Incident Cases of HF Segmented by Ventricular Dysfunction, Ages 45 Years, Both Sexes, N, 2015 44
Figure 7: 7MM, Diagnosed Incident Cases of Acute HF Hospitalizations, Ages 45 Years, Both Sexes, N, 2015-2025 45
Figure 8: 7MM, Diagnosed Incident Cases of Acute HF Hospitalizations, Ages 45 Years, Both Sexes, N, 2015 46
Figure 9: 7MM, Readmissions (Within Three Months) Post-Discharge After Acute HF Hospitalization Among Diagnosed Incident Cases of Acute HF, Ages 45 Years, Both Sexes, N, 2015-2025 48
Figure 10: 7MM, Hospital Length Of Stay For Acute HF Hospitalization, Ages 45 Years, Both Sexes, Days, 2015 49
Figure 11: 7MM, Diagnosed Prevalent Cases of Chronic HF, Ages 45 Years, Both Sexes, N, 2015-2025 51
Figure 12: 7MM, Age-Specific Diagnosed Prevalent Cases of Chronic HF, Both Sexes, N, 2015 53
Figure 13: 7MM, Sex-Specific Diagnosed Prevalent Cases of Chronic HF, Ages 45 Years, N, 2015 55
Figure 14: 7MM, Age-Standardized Diagnosed Prevalence of Chronic HF (%), Ages 45 Years, by Sex, 2015 56
Figure 15: 7MM, Diagnosed Prevalent Cases of Chronic HF Segmented by EF, Ages 45 Years, Both Sexes, N, 2015 57
Figure 16: 7MM, Diagnosed Prevalent Cases of Chronic HF Segmented by NYHA Classes, Ages 45 Years, Both Sexes, N, 2015 58
Figure 17: 7MM, Diagnosed Prevalent Cases of Chronic HF Segmented by ACCF/AHA Stages, Ages 45 Years, Both Sexes, N, 2015 59
Figure 18: 7MM, Prevalent Cases of Comorbidities Among Diagnosed Prevalent Cases of Chronic HF, Both Sexes, Ages 45 Years, N, 2015 60